1. Reasons for splitting of powder tablet press
(1) Compression formability of materials
The characteristics of raw materials, especially crystalline form.
Material adhesion, elastic deformation restoring force instantly exceeds the bonding force between particles, resulting in cracks.
The compressibility of the prescription and the bad compressibility of the prescription will lead to the inadequate hardness of the tablet. If the pressure is increased to increase the hardness, not only the hardness will not increase, but also cracking will occur.
(2) Process and equipment parameters
Particle properties: small particles, excessive fine powder, gas in the particles can not be effectively eliminated during the tablet pressing process, when the pressure is relieved, the air inside the tablet expands and causes cracks.
Pressure and speed of pressing: If the pressure is too high, the rebound force will also cause cracks. Most domestic tablet presses have smaller pre-press wheels and larger main press wheels. When pressing special-shaped tablets and traditional Chinese medicine tablets, the risk of cracks may arise because of insufficient material exhaust. Full exhaust during pre-pressing is particularly important for powder direct pressing products.
Sheet pressing die: The press die does not meet the requirements, and does not match with the die ring and other instrumental reasons lead to uneven pressure.
The environment of the tablet chamber: The tablet chamber has low room temperature and humidity, and is liable to cause cracks.
2. Suggestions for Resolving Fragments in Powder Compressor
Raw material processing: crushing or even micro-grinding of raw materials. Wet or dry granulation process is used to minimize the exposure of raw materials to particles and reduce the impact of raw materials on compressibility.
Improving the compressibility of materials: replacing more compressible auxiliary materials, reducing the speed of agitation and cutter in granulation, or using fluidized bed granulation, not only improve the compressibility, but also promote the dissolution increase. Adding micro-powder silica gel can obviously improve the compressibility of the particles and the hardness of the sheet under low pressure.
Improve the adhesiveness of materials: increase the concentration or dosage of adhesives to make hard particles, which can increase the mechanical force in the binding force of particles, thereby improving the adhesiveness of materials. Granules should not be too big or too hard. Shadows and hemp may appear. Reduce drying time and increase moisture content. Compressibility of materials with different drying time and moisture content was compared. When the particles are too dry, cracks will appear, but in general, qualified sheets can be extruded between 1% and 3%. The way of adding adhesives was investigated. The particle size of the adhesives is reduced or the adhesives are added in the form of solution to induce better adhesion. If wet granulation is used, it can be added both inside and outside. Choose stronger adhesives, such as HPMC, PVP, HPC and so on, among which the effect of HPC Zui is better.
Guangdong Rich Packing specializes in the production of powder tablets, if you need to contact us.