Our common tablets are pressed out with a tablet press, and they will not loosen because of the addition of a binder, the binding force between the particles in the tablet, the electrostatic adsorption force and the solid bridge.
Tablets now have different preparation processes such as wet granulation, dry granulation, and direct compression of powders.
The classic method is wet granulation. The main process is:
Crushing and mixing-crush and mix the active ingredients and related auxiliary materials evenly
Making soft materials-using appropriate wetting agents, adhesives, commonly used ethanol, starch syrup, the mixed medicine powder and agglomerate
Granulation-making soft materials into particles of uniform size
Drying-drying the particles
Tableting-the granules are compressed into a tablet by a tablet press, the shape of the tablet is determined by the shape of the mold
Coating—Sliced or enteric coating, film coating on the outside of pressed tablets (called vegetarian tablets), and many tablets are not coated.
Compared with wet granulation, dry granulation does not have the step of making soft materials. The mixed powder is directly compressed into granules and then compressed into tablets.
Direct compression of powder is to directly compress the mixed medicine powder into tablets, but it is required that the excipients have good compressibility and fluidity.