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The solution to the problem of preparation of sliver, adhesive punch and uneven content tablets

May 14, 2020

The solution to the problem of preparation of sliver, adhesive punch and uneven content tablets

中文 ZP-17-19侧面

With the development of medicine, various therapeutic methods advance by leaps and bounds, and the types of tablets increase day by day, including oral common tablets, lozenge tablets, sublingual tablets, oral patch, chewing tablets, dispersible tablets, etc.

With the rapid development of pharmacokinetics and material science, the technology and improvement of tablet are also changing with each passing day. At present, tablets are being integrated with nanomaterials, mainly used in the development of some insoluble drugs.

Tablets have many advantages, such as accurate dosage, easy to take, transportation, use, easy to carry and so on. In addition, by the outside air, water, light and other less influence, chemical properties are more stable.

In terms of production, the production is highly mechanized and automated, with low production cost, large output and low selling price. There are many kinds and they are widely used. In addition to its advantages, the tablet also has some disadvantages. For example, infants and coma patients are not easy to swallow; The content of some tablets containing volatile components will decrease during storage. Compared with other solid preparations, the preparation process is more and the technical difficulty is higher.

In the process of tablet preparation, some problems often occur, such as lobes, loose tablets, adhesion and punching. When faced with these problems, how should users treat and solve them?

A crack in a tablet is also called a crack, and if the crack occurs at the top (or bottom) of the tablet, it is usually called an apical crack, which is a common form of a crack. The uneven distribution of pressure and the resulting difference in elastic recovery rate are the main causes of the lobes.

In order to solve the sliver problem, the key is to use the auxiliary material with small elasticity and large plasticity to reduce the elastic recovery rate of the material on the whole. In addition, particles in the fine powder too much, particles too dry, adhesive viscosity is weak or insufficient, tablets too thick and pressure too fast can also cause lobes.

The surface of the tablet is stuck to a thin layer or a small part by the punch, resulting in a one-sided rough or concave phenomenon, usually is the adhesive punch; If the edge of the tablet is rough or marked, it can be called mucous membrane accordingly.

The main reasons for sticking or mucous membrane are: particles are not dry enough or materials are easy to absorb moisture, improper selection of lubricants, or insufficient dosage, and the surface of the punch is corroded or the lettering is rough and not smooth. Users should be based on the actual situation, determine the reasons to solve.

If the weight of the tablet exceeds the allowable range of the weight difference stipulated in the pharmacopoeial, there may be four reasons: poor particle fluidity, more or less particles flowing into the mold, resulting in a large difference in the weight of the tablet. Therefore, it is necessary to re-pellete or add better flow AIDS, such as micro-powder silica gel, to improve the particle fluidity.

Second, the tablet press if the particle size of the powder is too much or the particle size difference, resulting in the flow of material into the mold hole when heavy or light, should be removed too much powder or re-granulation.

Thirdly, when the pharmaceutical powder pressing machine adds more or less particles in the hopper, it will cause the fluctuation of the weight of the feed and lead to the over-limit of the difference in the weight of the sheet. Therefore, more than 1/3 of the particles should be kept in the hopper at all times.

Fourth, the punch of the automatic tablet press is not in good agreement with the die hole. For example, more powder is missing between the die hole wall and the outer edge of the down flush, resulting in the phenomenon of down flush and astringent flush, which will inevitably result in insufficient material filling. For this, the user should replace the punch, die ring.

If the content of tablets is not uniform, some experts say that all the factors causing the large difference in the weight of tablets can cause the uneven content of drugs in tablets. In addition, for small doses of drugs, uneven mixing and the migration of soluble components are the two main reasons for the unqualified uniformity of tablet content.