Direct tablet pressing is very important in the selection of excipients. In addition to the function of general tablet excipients, one of the primary excipients should have outstanding fluidity and tablet compression, and must also have appropriate accumulation density and larger drug absorption ability (i.e. ", adding more drugs without liquidity and pressure may have significant adverse effects. Accessories commonly used for direct tablet pressing include:
Microcrystalline cellulose This product is white or white powder, odorless, tasteless, insoluble in water, ethanol, acetone or toluene, has a good shrinkage, and has certain fluidity and disintegration, is an excellent tablet filler and effective dry binder, after pressing into the tablet has outstanding hardness, does not affect the disintegration. This species is highly resistant to drugs, with dosages ranging from 5% to 65%. But this species is hygroscopic. The international products are now available.
This product is white powder, odorless, tasteless, good fluidity, national product seclusion 36.6 degrees, tight; Smooth to reduce the force of the tablet ejecting from the die hole. Good disintegration and dry adhesion, can increase the hardness of tablets, reduce brittleness. This product is an ideal multifunctional auxiliary material for powder pressing tablets directly, the dosage is usually 5% ~ 20%.
Calcium hydrogen phosphate is a white powder, odorless, tasteless, insoluble in water or ethanol, with moisture resistance; Good liquidity and stability, high price; The hardness of the tablet is good. When the tablet contains 50% calcium bisphosphate, it differentiates rapidly.
This product is a pale white anhydrous powder, odorless, tasteless, larger than the appearance, often used as a tablet flow aid, has a greater adhesion to drugs. Its hydrophilic ability is strong, the dosage is more than 1%, can slow down the disintegration of the tablet, and the disintegration is very precise, so as to improve the dissolution of the drug, beneficial to the reception of the drug. General dosage 0.15% ~ 3%.
Lactose Spray Dry Lactose is an adjunct for powder direct suppression. It is a white crystalline powder with no hygroscopic properties. The tablet appearance is lubricated and beautiful, and the drug release is quick. Excellent mobility and capacity. It is an ideal filling agent for tablets. When the dosage is greater than 50%, the hydrophobicity of the drug can be improved.
Sodium carboxymethyl starch this product is an excellent disintegrating agent for tablets, white or white powder, odorless, there is water in the air, at the level of dispersed into thin colloidal solution; It has outstanding hydrophilicity and water absorption shrinkage. It has excellent fluidity and shrinkage, which improves the formability of the tablet and enhances the hardness of the tablet without affecting the disintegration of the tablet. For insoluble drug tablets, this product can be modified to disintegrate. The general dosage is 1% ~ 8%.
Magnesium stearate This product is white and easy to sand fine powder. It has a smooth feeling on contact with the skin. Insoluble in water, with good yield. This product is a frequently used hydrophobic smoothing agent, can effectively deal with the adhesion scene, single lubrication beautiful. The general dosage is 0.2% ~ 1%.
Other such as low instead of hydroxypropyl cellulose, starch, talcum powder - magnesium stearate mixed powder, aluminum magnesium cornstarch, etc.